Prospective Evaluation of Cyberknife Stereotactic Radiosurgery for Low and Intermediate Risk Prostate Cancer

Service: Trial Number:
Principal Investigator: Conducted at:
Orange Coast Memorial
Currently enrolling additional patients:

Due to the advances in being able to detect early stage prostate cancer better than before, more and more men diagnosed with the disease are able to be cured. Methods of prostate cancer treatment include having laparoscopic surgery (a procedure that is performed through small incisions), having open surgery to remove the prostate leaving a larger incision, receiving radiation therapy, or brachytherapy (placing high energy x-rays to destroy the cancer cells). The CyberKnife system is a new type of radiation machine that uses a special system to precisely focus large doses of x-rays on the tumor. The device is designed to concentrate large doses of radiation onto the tumor specifically so that injury from radiation to the nearby normal tissue would be minimal. Patients agreeing to participate in this study will be asked to complete questionnaires before the CyberKnife treatment. These questionnaires will ask multiple choice questions about bowel, bladder and sexual function and general questions about mood, activity and energy levels, and general health. Subjects will also have a physical examination and a procedure to place 3 to 5 small gold seeds into the prostate. These gold markers will be used to determine the location of the prostate during the CyberKnife treatment. The course of radiation will consist of five separate CyberKnife treatments usually delivered over 5 weekdays (maximum 14 days), with no less than 12 hours between any two fractions (increments of a full dose). The follow-up visits will be at 1, 3 and 6 months and every 6 months post treatment for 5 years.

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