A Phase 3b, Open-Label, Parallel Group, Randomized, Multicenter Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone For Myocardial Perfusion Imaging (MPI)…

Service: Trial Number:
101-12
Principal Investigator: Conducted at:
Long Beach Memorial
Currently enrolling additional patients:
Yes

A Phase 3b, Open-Label, Parallel Group, Randomized, Multicenter Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone For Myocardial Perfusion Imaging (MPI) Using Single Photon Emission Computed Tomography (SPECT) - EXERRT – EXErcise to Regadenoson in Recovery Trial. Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) is an important part of cardiology practice for diagnosing and managing coronary artery disease. This is a non-invasive test in which a radio-pharmaceutical is injected into a vein and a scan is done which shows the blood flow to the heart. Typically two scans are done; one at rest and one under a stress condition (like exercising on a treadmill). Exercise stress testing (patient walking on a treadmill) is the preferred method of stress testing and is useful in the diagnosis of coronary artery disease and is reveals superior images to those produced during a pharmaceutically produced stress test. Often times, patients do not reach the optimal heart rate during an exercise stress test and a drug is injected that stimulates this “stress” situation on the heart. Regadenoson is such an agent. However, true exercise has been found to produce the best images and tend to reveal more accurate information about coronary artery disease. This study proposes that for patients who cannot complete an exercise stress test, regadenoson is given in the recovery phase of the stress test (3 minutes after the exercise and when the patient is still walking on the treadmill at a reduced rate) as opposed to waiting one hour. The hypothesis is that this will reveal a superior image when compared to a non-exercise stress scan. Subjects will be recruited from PI and sub-I clinical practice. Patients referred for exercise or pharmaceutical stress tests for coronary artery disease are the target population.

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