Dr. Sarah Liss was born and raised in Anchorage, Alaska. She completed her undergraduate degree at Western Oregon University where she received her Bachelor of Science degree in Biology. After a year of working at the Doernbech Children's Hospital in Portland, Oregon she continued her studies at the Medical College of Wisconsin to receive her M.D. She completed her pediatric residency at UCI.
Dr. Liss resides in Irvine with her husband.